abstract：BACKGROUND:Since the late 1990s, imaging studies have allowed the visualization of brain response to acupuncture stimulation with alteration in blood flow. In 1998, the first functional magnetic resonance imaging (fMRI) study for the Korean acupuncture was published and thereafter, many subsequent neuroimaging studies ...

journal_title：Neurological research

authors： Chae Y,Park HJ,Hahm DH,Hong M,Ha E,Park HK,Lee H

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:Cerebral hypoxia-ischemia leads to the depletion of ATP. Hypoxanthine, a degradation product of ATP, can be salvaged by hypoxanthine phosphoribosyl transferase (HPRT) and used to reform high-energy purines. Hypothermia conserves ATP in hypoxia-ischemia, possibly by preserving HPRT activity. We hypothesized t...

journal_title：Neurological research

authors： Cherin T,Catbagan M,Treiman S,Mink R

更新日期：2006-12-01 00:00:00

abstract：:Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refracto...

journal_title：Neurological research

authors： Ahn JY,Han IB,Chung SS,Chung YS,Kim SH,Yoon PH

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Crossed-uncrossed differentials (CUDs) are viewed as surrogates for interhemispheric transfer time (IHTT). Not uncommonly CUDs assume statistically significant negative values (inverted CUDs). This raises doubts of the accepted interpretation of CUDs, i.e. intra- and inter-hemispheric routings of signals in ...

journal_title：Neurological research

authors： Derakhshan I

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:To review the historical development and current status of endovascular techniques used in the treatment of symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. METHODS:This article summarizes the relevant literature on neurointerventional therapy for vasospasm, namely instillation of intraar...

journal_title：Neurological research

authors： Brisman JL,Eskridge JM,Newell DW

更新日期：2006-10-01 00:00:00

abstract：:Dementia is one of the commonest neurological disorders in the elderly population. In regards to the increasing longevity of populations worldwide, prevention of dementia has become a major public health challenge. There has been an intense research in the identification of modifiable risk factors for dementia. These ...

journal_title：Neurological research

authors： Bergmann C,Sano M

更新日期：2006-09-01 00:00:00

abstract：:The goal of this paper is to provide scientists with a comprehensive review of the state-of-the-art influence the ischemic blood-brain barrier (BBB) has on the final development of Alzheimer's disease and to provide detailed food-for-thought which will hopefully stimulate more researchers in this area of neuroscience....

journal_title：Neurological research

authors： Pluta R

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to characterize mouse neural stem cells (NSC) transduced by a multigenic lentiviral vector (LV) and stably express recombinant human nerve growth factor (rhNGF). We obtained NSC-derived cell lines which express human NGF in relevant amount to exploit their ability for therapeuti...

journal_title：Neurological research

authors： Cenciarelli C,Budoni M,Mercanti D,Fernandez E,Pallini R,Aloe L,Cimino V,Maira G,Casalbore P

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Diffusion-weighted imaging (DWI) abnormalities can frequently be detected after carotid endarterectomy (CEA) and carotid angioplasty with stent placement (CAS) of the carotid arteries. We looked for possible predictors for the development of DWI lesions during the intervention. METHODS:We investigated 41 pa...

journal_title：Neurological research

authors： Poppert H,Wolf O,Theiss W,Heider P,Hollweck R,Roettinger M,Sander D

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:Ischemia/hypoxia (I/H) causes severe neonatal brain injury, such as periventricular leukomaracia and hypoxic/ischemic encephalopathy. Neural stem cell research could lead to a treatment for such disorders. In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we inve...

journal_title：Neurological research

authors： Iwai M,Ikeda T,Hayashi T,Sato K,Nagata T,Nagano I,Shoji M,Ikenoue T,Abe K

更新日期：2006-06-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) remains unknown. However, both genetic and environmental factors play important roles in its pathogenesis. While demyelination of axons is a hallmark histological feature of MS, axonal and neuronal dysfunction may correlate better with clinical disability. All major immune cell ...

journal_title：Neurological research

authors： McDole J,Johnson AJ,Pirko I

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:To describe the role of neurosurgical techniques in treatment of symptoms of multiple sclerosis (MS). METHODS:A review of the existing world literature searching (using PubMed, August 22, 2005) for key words 'multiple sclerosis' and multiple symptoms associated with MS including trigeminal neuralgia, pain (...

journal_title：Neurological research

authors： Patwardhan RV,Minagar A,Kelley RE,Nanda A

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:This study assesses the clinical outcome after early combined cranioplasty (own frozen bone) and shunt implantation (Codman-Medos programmable VP shunt) in patients with skull bone defects and cerebrospinal fluid (CSF) circulation disorders. METHOD:Medical records were reviewed retrospectively for the last 1...

journal_title：Neurological research

authors： Carvi Y Nievas MN,Höllerhage HG

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Changes in systemic arterial blood pressure and the degree of cerebral vasospasm were investigated in 125 patients with aneurysmal subarachnoid hemorrhage. METHODS:Systemic arterial blood pressure was measured every 2 hours in each patient for a period of more than 2 weeks, and a fall in systemic blood pres...

journal_title：Neurological research

authors： Tabuchi S,Hirano N,Tanabe M,Kurosaki M,Okamoto H,Kamitani H,Yokota M,Watanabe T

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To explore the primary regularity of cerebral electrical impedance (CEI) change in healthy people, patients with intracerebral hemorrhage (ICH) and patients with cerebral infarction (CI). METHODS:CEI of 200 healthy volunteers, 78 patients with ICH and 51 patients with CI were measured by noninvasive brain-ed...

journal_title：Neurological research

authors： Liu L,Dong W,Ji X,Chen L,Chen L,He W,Jia J

更新日期：2006-01-01 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in normal developing brain, but the role of nNOS in neurogenesis in the ischemic brain remains unclear. To investigate the temporal and spatial relationship between cell proliferation of the ependymal/subventricular zone (SVZ), a principal neuroproliferative...

journal_title：Neurological research

authors： Zhang P,Liu Y,Li J,Kang Q,Tian Y,Chen X,Shi Q,Song T

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The goals of the present study are to obtain, expand and characterize a stem cell population from human omentum and to evaluate its in vivo angiogenic capacities. METHODS:Human omental CD34+ cells were obtained from samples of human omentum by density gradient centrifugation in Ficoll. Proliferative pattern...

journal_title：Neurological research

authors： García-Gómez I,Goldsmith HS,Angulo J,Prados A,López-Hervás P,Cuevas B,Dujovny M,Cuevas P

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:To estimate the incidence of cognitive impairment (CI) among cognitively healthy, Mexican subjects, and to evaluate the impact of demographic and vascular factors on the conversion to CI and mortality. METHODS:734 eligible subjects (aged 55 to >90 years) from a population-based sample were examined. The cog...

journal_title：Neurological research

authors： Arauz A,Alonso E,Rodríguez-Saldaña J,Reynoso-Marenco M,Benitez IT,Mayorga AM,Rodríguez-Agudelo Y,Romero AV,Cantú C

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVES:To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system. METHODS:Systematic review of the English literature. RESULTS:Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug meta...

journal_title：Neurological research

authors： Meriggioli MN

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to analyse inflammatory cells in lumbar disc tissue under cyclooxygenase-2 (COX-2) inhibitor therapy, to detect their prevalence in different subtypes of lumbar disc herniations and to assess the influence of inflammatory reactions in herniated disc tissue on postoperative out...

journal_title：Neurological research

authors： Aydin MV,Sen O,Kayaselcuk F,Bolat F,Tufan K,Caner H,Altinors N

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:In the clinical set, autologus nerve grafts are the current option for reconstruction of nerve tissue losses. The length of the nerve graft has been suggested to affect outcomes. Experiments were performed in the rat in order to test this assumption and to detect a possible mechanism to explain differences i...

journal_title：Neurological research

authors： Bertelli JA,Taleb M,Mira JC,Ghizoni MF

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Daughter aneurysms have been strongly associated with saccular aneurysm rupture. We constructed a mathematical model to help explain this association as a possible hemodynamic mechanism for intracranial saccular aneurysm rupture. METHODS:Our model is based on the assumption that when an aneurysm reaches a s...

journal_title：Neurological research

authors： Meng H,Feng Y,Woodward SH,Bendok BR,Hanel RA,Guterman LR,Hopkins LN

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The presence of beta-amyloid (betaA) deposition, induction of reactive gliosis and dystrophic neurites, is a characteristic feature of neuritic plaques in Alzheimer's disease. In vitro, betaA-exposed astrocytes become reactive, similar to astrocytes in contact with betaA plaques in vivo. How betaA-exposed re...

journal_title：Neurological research

authors： Monnerie H,Esquenazi S,Shashidhara S,Le Roux PD

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The stroke-prone spontaneously hypertensive rat is a genetic model of severe hypertension with secondary vascular alterations. The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature. METHODS:The study c...

journal_title：Neurological research

authors： Liebetrau M,Burggraf D,Büscher C,Linz W,Hamann GF

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The present study characterized glial cell injury provoked in adult rat chiasm within 24 hours after a single, high-dose irradiation of 20 Gy. METHODS:All chiasmal glial cells in a section were counted, and the percentage of TUNEL-positive glial cells exhibiting apoptotic morphology was defined as the apopt...

journal_title：Neurological research

authors： Nagayama K,Kurita H,Nakamura M,Kusuda J,Tonari A,Takayama M,Fujioka Y,Shiokawa Y

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:We tested whether repetitive magnetic stimulation (rMS) induces an afferent input to the spinocerebral tract in patients with complex regional pain syndrome (CRPS). METHODS:Cortical and spinal motor evoked potentials (cMEP and sMEP), as well as the contra- and ipsilateral silent period (cCSP and iCSP), were...

journal_title：Neurological research

authors： Krause P,Foerderreuther S,Straube A

更新日期：2005-06-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) remains a major medical problem, for which there is no effective treatment. However, extensive experimental and clinical research carried out in recent years has brought to light new exciting ideas for novel potential treatments. First, it was well documented that the management of hyper...

journal_title：Neurological research

authors： Aronowski J,Hall CE

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia. METHODS:Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. RESULTS:A(2A) ant...

journal_title：Neurological research

authors： Pedata F,Gianfriddo M,Turchi D,Melani A

更新日期：2005-03-01 00:00:00

abstract：:We have reliable data on the degree of stenosis above which endarterectomy for symptomatic carotid stenosis is beneficial, but benefit is also influenced by other factors, particularly age, sex, the timing of surgery, plaque surface morphology and the nature of the presenting symptomatic event(s). This review will con...

journal_title：Neurological research

authors： Rothwell PM

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To evaluate by MR diffusion weighted image (DWI-MR) the presence of new ischemic cerebral lesions after carotid artery stenting (CAS) and distal cerebral protection, in patients with internal carotid artery (ICA) stenosis >70. METHODS:Sixty-seven CAS were performed under cerebral protection with a distal fil...

journal_title：Neurological research

authors： González A,Piñero P,Martínez E,González-Marcos JR,Rafel E,Mayol A,Gil-Peralta A

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The feasibility of high resolution CT imaging for evaluating experimentally-induced brain tumors in rats was assessed. METHODS:The gliosarcoma cell line (9 L/lacZ) was inoculated in 34 male Fischer 344 rats and CT studies were performed prior to and at 4, 7, 9, 12 and 14 days post-tumor cell implantation. Br...

journal_title：Neurological research

authors： Psarros TG,Mickey B,Giller C

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Patent foramen ovale (PFO) is considered as an important risk factor for cerebrovascular diseases. Nevertheless, the relationship between the distribution of high-intensity transient signals (HITS), resulting from injection of air mixed with saline and detected by transcranial Doppler (TCD), and clinical cer...

journal_title：Neurological research

authors： Telman G,Kouperberg E,Sprecher E,Goldsher D,Yarnitsky D

更新日期：2005-01-01 00:00:00

abstract：:It is being increasingly suggested that the microcirculation, which is known to be in a large part responsible for maintaining an adequate and constant microenvironment for function of the central nervous system, functions as part of a neurovascular unit. The neurovascular unit includes neurons, astrocytes and element...

journal_title：Neurological research

authors： Takahashi M,Macdonald RL

更新日期：2004-12-01 00:00:00

abstract：:This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs and symptoms, imaging diagnosis, indication for surgical treatment, and surgical procedures. Anomalies that cause mechanical spinal cord tethering are listed, and the surgical untethering...

journal_title：Neurological research

authors： Yamada S,Won DJ,Siddiqi J,Yamada SM

更新日期：2004-10-01 00:00:00

abstract：:Lectin-like oxidized low-density lipoprotein receptor (LOX-1) and monocyte chemoattractant protein-1 (MCP-1) are molecules involving in the initiation and progression of atherosclerosis. In order to examine a possible difference in LOX-1 and MCP-1 expressions depending on the severity of early stage of atherosclerosis...

journal_title：Neurological research

authors： Hamakawa Y,Omori N,Ouchida M,Nagase M,Sato K,Nagano I,Shoji M,Fujita T,Abe K

更新日期：2004-10-01 00:00:00

abstract：:The application of optical spectroscopy for intra-operatively delineating brain tumors has been studied in this paper. The classification of tissue as normal, tumor and boundary is done using the LAMSTAR neural network (NN). The objective is to combine both fluorescence and reflectance as attributes to be used for the...

journal_title：Neurological research

authors： Sivaramakrishnan A,Graupe D

更新日期：2004-09-01 00:00:00

abstract：:We investigated the neuroprotective effects of a novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (pitavastatin) on ischemic neuronal damage in gerbils using immunohistochemistry. The animals were allowed to survive for 14 days after 5 min of ischemia induced by bilateral occlusion of the comm...

journal_title：Neurological research

authors： Kurosaki R,Muramatsu Y,Kato H,Araki T

更新日期：2004-09-01 00:00:00

abstract：:We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelming amyloid accumulation in the walls of leptomeningeal and cortical ...

journal_title：Neurological research

authors： Kalback W,Esh C,Castaño EM,Rahman A,Kokjohn T,Luehrs DC,Sue L,Cisneros R,Gerber F,Richardson C,Bohrmann B,Walker DG,Beach TG,Roher AE

更新日期：2004-07-01 00:00:00

abstract：:Mild vascular cognitive impairment (mVCI) is a broader term that is intended to detect cognitive loss before the development of dementia. The identification of preventable risk factors as well as therapeutic strategies of intervention is still unclear. It has been suggested that carotid endarterectomy (CEA) improves c...

journal_title：Neurological research

authors： Borroni B,Tiberio G,Bonardelli S,Cottini E,Facheris M,Akkawi N,Pezzini A,Cervi E,Giulini SM,Padovani A

更新日期：2004-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of the dopamine producing neurons projecting from the substantia nigra into the corpus striatum. Current medical therapy is limited and cannot stop or reverse the degeneration. Over the past 30 years, attempts were m...

journal_title：Neurological research

authors： Roitberg B,Urbaniak K,Emborg M

更新日期：2004-06-01 00:00:00